A five-residue motif for the design of domain swapping in proteins

Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and structurally unrelated host proteins, providing...

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Autores principales:	Neha Nandwani, Parag Surana, Hitendra Negi, Nahren M. Mascarenhas, Jayant B. Udgaonkar, Ranabir Das, Shachi Gosavi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9b6bdc87e3ab4b35a3fc024b6c07e914
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spelling	oai:doaj.org-article:9b6bdc87e3ab4b35a3fc024b6c07e9142021-12-02T17:01:55ZA five-residue motif for the design of domain swapping in proteins10.1038/s41467-019-08295-x2041-1723https://doaj.org/article/9b6bdc87e3ab4b35a3fc024b6c07e9142019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08295-xhttps://doaj.org/toc/2041-1723Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and structurally unrelated host proteins, providing a simple approach to the design of protein assemblies.Neha NandwaniParag SuranaHitendra NegiNahren M. MascarenhasJayant B. UdgaonkarRanabir DasShachi GosaviNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neha Nandwani Parag Surana Hitendra Negi Nahren M. Mascarenhas Jayant B. Udgaonkar Ranabir Das Shachi Gosavi A five-residue motif for the design of domain swapping in proteins
description	Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and structurally unrelated host proteins, providing a simple approach to the design of protein assemblies.
format	article
author	Neha Nandwani Parag Surana Hitendra Negi Nahren M. Mascarenhas Jayant B. Udgaonkar Ranabir Das Shachi Gosavi
author_facet	Neha Nandwani Parag Surana Hitendra Negi Nahren M. Mascarenhas Jayant B. Udgaonkar Ranabir Das Shachi Gosavi
author_sort	Neha Nandwani
title	A five-residue motif for the design of domain swapping in proteins
title_short	A five-residue motif for the design of domain swapping in proteins
title_full	A five-residue motif for the design of domain swapping in proteins
title_fullStr	A five-residue motif for the design of domain swapping in proteins
title_full_unstemmed	A five-residue motif for the design of domain swapping in proteins
title_sort	five-residue motif for the design of domain swapping in proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9b6bdc87e3ab4b35a3fc024b6c07e914
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A five-residue motif for the design of domain swapping in proteins

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