Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-fr...

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Bibliographic Details
Main Authors: Andrea Imle, Peter Kumberger, Nikolas D. Schnellbächer, Jana Fehr, Paola Carrillo-Bustamante, Janez Ales, Philip Schmidt, Christian Ritter, William J. Godinez, Barbara Müller, Karl Rohr, Fred A. Hamprecht, Ulrich S. Schwarz, Frederik Graw, Oliver T. Fackler
Format: article
Language:EN
Published: Nature Portfolio 2019
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Science
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Online Access:https://doaj.org/article/9b883324a99d4e44ab53be00321fd321
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https://doaj.org/article/9b883324a99d4e44ab53be00321fd321

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