Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures
Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-fr...
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/9b883324a99d4e44ab53be00321fd321 |
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oai:doaj.org-article:9b883324a99d4e44ab53be00321fd3212021-12-02T16:57:55ZExperimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures10.1038/s41467-019-09879-32041-1723https://doaj.org/article/9b883324a99d4e44ab53be00321fd3212019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09879-3https://doaj.org/toc/2041-1723Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-free virions.Andrea ImlePeter KumbergerNikolas D. SchnellbächerJana FehrPaola Carrillo-BustamanteJanez AlesPhilip SchmidtChristian RitterWilliam J. GodinezBarbara MüllerKarl RohrFred A. HamprechtUlrich S. SchwarzFrederik GrawOliver T. FacklerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Andrea Imle Peter Kumberger Nikolas D. Schnellbächer Jana Fehr Paola Carrillo-Bustamante Janez Ales Philip Schmidt Christian Ritter William J. Godinez Barbara Müller Karl Rohr Fred A. Hamprecht Ulrich S. Schwarz Frederik Graw Oliver T. Fackler Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures |
| description |
Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-free virions. |
| format |
article |
| author |
Andrea Imle Peter Kumberger Nikolas D. Schnellbächer Jana Fehr Paola Carrillo-Bustamante Janez Ales Philip Schmidt Christian Ritter William J. Godinez Barbara Müller Karl Rohr Fred A. Hamprecht Ulrich S. Schwarz Frederik Graw Oliver T. Fackler |
| author_facet |
Andrea Imle Peter Kumberger Nikolas D. Schnellbächer Jana Fehr Paola Carrillo-Bustamante Janez Ales Philip Schmidt Christian Ritter William J. Godinez Barbara Müller Karl Rohr Fred A. Hamprecht Ulrich S. Schwarz Frederik Graw Oliver T. Fackler |
| author_sort |
Andrea Imle |
| title |
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures |
| title_short |
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures |
| title_full |
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures |
| title_fullStr |
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures |
| title_full_unstemmed |
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures |
| title_sort |
experimental and computational analyses reveal that environmental restrictions shape hiv-1 spread in 3d cultures |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/9b883324a99d4e44ab53be00321fd321 |
| work_keys_str_mv |
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