Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective function, and shows efficacy in animal models.
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Nature Portfolio
2020
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oai:doaj.org-article:9ba7c3d64bcb4b03984dbf3b38cd94db2021-12-02T14:59:27ZTargeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia10.1038/s41467-020-16720-92041-1723https://doaj.org/article/9ba7c3d64bcb4b03984dbf3b38cd94db2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16720-9https://doaj.org/toc/2041-1723Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective function, and shows efficacy in animal models.Xiao-Yan ZhaoAndreas WilmenDongli WangXinquan WangMaxine BauzonJi-Yun KimLars LindenLiang LiUrsula EgnerTobias MarquardtDieter MoosmayerJan TebbeJulian Marius GlückPhilipp EllingerKirk McLeanShujun YuanSubramanian YegneswaranXiaoqiao JiangVince EvansJian-Ming GuDoug SchneiderYing ZhuYifan XuCornell MallariAshley HessleinYan WangNicole SchmidtKatrin GutberletChristine Ruehl-FehlertAlexius FreybergerTerry HermistonChandra PatelDerek SimLaurent O. MosnierVolker LauxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Xiao-Yan Zhao Andreas Wilmen Dongli Wang Xinquan Wang Maxine Bauzon Ji-Yun Kim Lars Linden Liang Li Ursula Egner Tobias Marquardt Dieter Moosmayer Jan Tebbe Julian Marius Glück Philipp Ellinger Kirk McLean Shujun Yuan Subramanian Yegneswaran Xiaoqiao Jiang Vince Evans Jian-Ming Gu Doug Schneider Ying Zhu Yifan Xu Cornell Mallari Ashley Hesslein Yan Wang Nicole Schmidt Katrin Gutberlet Christine Ruehl-Fehlert Alexius Freyberger Terry Hermiston Chandra Patel Derek Sim Laurent O. Mosnier Volker Laux Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia |
| description |
Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Here, the authors develop a monoclonal antibody that specifically inhibits APC’s anticoagulant function without compromising its cytoprotective function, and shows efficacy in animal models. |
| format |
article |
| author |
Xiao-Yan Zhao Andreas Wilmen Dongli Wang Xinquan Wang Maxine Bauzon Ji-Yun Kim Lars Linden Liang Li Ursula Egner Tobias Marquardt Dieter Moosmayer Jan Tebbe Julian Marius Glück Philipp Ellinger Kirk McLean Shujun Yuan Subramanian Yegneswaran Xiaoqiao Jiang Vince Evans Jian-Ming Gu Doug Schneider Ying Zhu Yifan Xu Cornell Mallari Ashley Hesslein Yan Wang Nicole Schmidt Katrin Gutberlet Christine Ruehl-Fehlert Alexius Freyberger Terry Hermiston Chandra Patel Derek Sim Laurent O. Mosnier Volker Laux |
| author_facet |
Xiao-Yan Zhao Andreas Wilmen Dongli Wang Xinquan Wang Maxine Bauzon Ji-Yun Kim Lars Linden Liang Li Ursula Egner Tobias Marquardt Dieter Moosmayer Jan Tebbe Julian Marius Glück Philipp Ellinger Kirk McLean Shujun Yuan Subramanian Yegneswaran Xiaoqiao Jiang Vince Evans Jian-Ming Gu Doug Schneider Ying Zhu Yifan Xu Cornell Mallari Ashley Hesslein Yan Wang Nicole Schmidt Katrin Gutberlet Christine Ruehl-Fehlert Alexius Freyberger Terry Hermiston Chandra Patel Derek Sim Laurent O. Mosnier Volker Laux |
| author_sort |
Xiao-Yan Zhao |
| title |
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia |
| title_short |
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia |
| title_full |
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia |
| title_fullStr |
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia |
| title_full_unstemmed |
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia |
| title_sort |
targeted inhibition of activated protein c by a non-active-site inhibitory antibody to treat hemophilia |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/9ba7c3d64bcb4b03984dbf3b38cd94db |
| work_keys_str_mv |
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1718389218681552896 |