Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Frizzled 6 (FZD6) is a G protein-coupled receptor (GPCR) involved in several cellular processes. Here, the authors use live cell imaging and spectroscopy to show that FZD6 forms dimers, whose association is regulated by WNT proteins and that dimer dissociation is crucial for FZD6 signaling.

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Autores principales: Julian Petersen, Shane C. Wright, David Rodríguez, Pierre Matricon, Noa Lahav, Aviv Vromen, Assaf Friedler, Johan Strömqvist, Stefan Wennmalm, Jens Carlsson, Gunnar Schulte
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/9bbfbda480b54f6599ce12e240732064
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https://doaj.org/article/9bbfbda480b54f6599ce12e240732064

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