Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Frizzled 6 (FZD6) is a G protein-coupled receptor (GPCR) involved in several cellular processes. Here, the authors use live cell imaging and spectroscopy to show that FZD6 forms dimers, whose association is regulated by WNT proteins and that dimer dissociation is crucial for FZD6 signaling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Julian Petersen, Shane C. Wright, David Rodríguez, Pierre Matricon, Noa Lahav, Aviv Vromen, Assaf Friedler, Johan Strömqvist, Stefan Wennmalm, Jens Carlsson, Gunnar Schulte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9bbfbda480b54f6599ce12e240732064
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9bbfbda480b54f6599ce12e240732064
record_format	dspace
spelling	oai:doaj.org-article:9bbfbda480b54f6599ce12e2407320642021-12-02T13:57:32ZAgonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling10.1038/s41467-017-00253-92041-1723https://doaj.org/article/9bbfbda480b54f6599ce12e2407320642017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00253-9https://doaj.org/toc/2041-1723Frizzled 6 (FZD6) is a G protein-coupled receptor (GPCR) involved in several cellular processes. Here, the authors use live cell imaging and spectroscopy to show that FZD6 forms dimers, whose association is regulated by WNT proteins and that dimer dissociation is crucial for FZD6 signaling.Julian PetersenShane C. WrightDavid RodríguezPierre MatriconNoa LahavAviv VromenAssaf FriedlerJohan StrömqvistStefan WennmalmJens CarlssonGunnar SchulteNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julian Petersen Shane C. Wright David Rodríguez Pierre Matricon Noa Lahav Aviv Vromen Assaf Friedler Johan Strömqvist Stefan Wennmalm Jens Carlsson Gunnar Schulte Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
description	Frizzled 6 (FZD6) is a G protein-coupled receptor (GPCR) involved in several cellular processes. Here, the authors use live cell imaging and spectroscopy to show that FZD6 forms dimers, whose association is regulated by WNT proteins and that dimer dissociation is crucial for FZD6 signaling.
format	article
author	Julian Petersen Shane C. Wright David Rodríguez Pierre Matricon Noa Lahav Aviv Vromen Assaf Friedler Johan Strömqvist Stefan Wennmalm Jens Carlsson Gunnar Schulte
author_facet	Julian Petersen Shane C. Wright David Rodríguez Pierre Matricon Noa Lahav Aviv Vromen Assaf Friedler Johan Strömqvist Stefan Wennmalm Jens Carlsson Gunnar Schulte
author_sort	Julian Petersen
title	Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
title_short	Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
title_full	Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
title_fullStr	Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
title_full_unstemmed	Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling
title_sort	agonist-induced dimer dissociation as a macromolecular step in g protein-coupled receptor signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9bbfbda480b54f6599ce12e240732064
work_keys_str_mv	AT julianpetersen agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT shanecwright agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT davidrodriguez agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT pierrematricon agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT noalahav agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT avivvromen agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT assaffriedler agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT johanstromqvist agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT stefanwennmalm agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT jenscarlsson agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling AT gunnarschulte agonistinduceddimerdissociationasamacromolecularstepingproteincoupledreceptorsignaling
_version_	1718392336790061056

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Ejemplares similares