Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)

Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the preparation of Bacillus subtilis CNCM I‐4606, B. subtilis CNCM I‐5043, B. subtilis CNCM I‐4607 and Lactococcus la...

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Autores principales:	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Maria Saarela, Jaume Galobart, Matteo Innocenti, Joana Revez, Maria Vittoria Vettori, Rosella Brozzi
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	technological additive hygiene condition enhancer Bacillus subtilis CNCM I‐4606 Bacillus subtilis CNCM I‐5043 Bacillus subtilis CNCM I‐4607 Lactococcus lactis CNCM I‐4609 Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/9c3b08d7e8c244ff8a82f45044f51b71
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spelling	oai:doaj.org-article:9c3b08d7e8c244ff8a82f45044f51b712021-12-02T17:55:57ZSafety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)1831-473210.2903/j.efsa.2021.6907https://doaj.org/article/9c3b08d7e8c244ff8a82f45044f51b712021-11-01T00:00:00Zhttps://doi.org/10.2903/j.efsa.2021.6907https://doaj.org/toc/1831-4732Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the preparation of Bacillus subtilis CNCM I‐4606, B. subtilis CNCM I‐5043, B. subtilis CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 when used as a technological additive (hygiene condition enhancer) for all animal species. The product is intended for use in compound feeds and feed materials for all animal species at a minimum inclusion level of 1 × 109 CFU B. subtilis and 1 × 109 CFU L. lactis per kg or litre. The two bacterial species are considered by EFSA to be eligible for the qualified presumption of safety (QPS) approach. As the identity of the strains has been clearly established and they did not show acquired resistance to antibiotics of human and veterinary importance, the use of these strains in animal nutrition is considered safe for the target species, consumers and the environment. The additive is not irritant to skin and eyes or a skin sensitiser. Given the proteinaceous nature of the active agents, the additive should be considered a respiratory sensitiser. The Panel is not in the position to conclude on the efficacy of the additive to significantly reduce the growth of either Salmonella Typhimurium or Escherichia coli in feed.EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenBirgit DusemundMojca Fašmon DurjavaMaryline KoubaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaFernando RamosYolanda SanzRoberto Edoardo VillaRuud WoutersenMaria SaarelaJaume GalobartMatteo InnocentiJoana RevezMaria Vittoria VettoriRosella BrozziWileyarticletechnological additivehygiene condition enhancerBacillus subtilis CNCM I‐4606Bacillus subtilis CNCM I‐5043Bacillus subtilis CNCM I‐4607Lactococcus lactis CNCM I‐4609Nutrition. Foods and food supplyTX341-641Chemical technologyTP1-1185ENEFSA Journal, Vol 19, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	technological additive hygiene condition enhancer Bacillus subtilis CNCM I‐4606 Bacillus subtilis CNCM I‐5043 Bacillus subtilis CNCM I‐4607 Lactococcus lactis CNCM I‐4609 Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185
spellingShingle	technological additive hygiene condition enhancer Bacillus subtilis CNCM I‐4606 Bacillus subtilis CNCM I‐5043 Bacillus subtilis CNCM I‐4607 Lactococcus lactis CNCM I‐4609 Nutrition. Foods and food supply TX341-641 Chemical technology TP1-1185 EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Mojca Fašmon Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Maria Saarela Jaume Galobart Matteo Innocenti Joana Revez Maria Vittoria Vettori Rosella Brozzi Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)
description	Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the preparation of Bacillus subtilis CNCM I‐4606, B. subtilis CNCM I‐5043, B. subtilis CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 when used as a technological additive (hygiene condition enhancer) for all animal species. The product is intended for use in compound feeds and feed materials for all animal species at a minimum inclusion level of 1 × 109 CFU B. subtilis and 1 × 109 CFU L. lactis per kg or litre. The two bacterial species are considered by EFSA to be eligible for the qualified presumption of safety (QPS) approach. As the identity of the strains has been clearly established and they did not show acquired resistance to antibiotics of human and veterinary importance, the use of these strains in animal nutrition is considered safe for the target species, consumers and the environment. The additive is not irritant to skin and eyes or a skin sensitiser. Given the proteinaceous nature of the active agents, the additive should be considered a respiratory sensitiser. The Panel is not in the position to conclude on the efficacy of the additive to significantly reduce the growth of either Salmonella Typhimurium or Escherichia coli in feed.
format	article
author	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Mojca Fašmon Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Maria Saarela Jaume Galobart Matteo Innocenti Joana Revez Maria Vittoria Vettori Rosella Brozzi
author_facet	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Mojca Fašmon Durjava Maryline Kouba Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Fernando Ramos Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Maria Saarela Jaume Galobart Matteo Innocenti Joana Revez Maria Vittoria Vettori Rosella Brozzi
author_sort	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
title	Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)
title_short	Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)
title_full	Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)
title_fullStr	Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)
title_full_unstemmed	Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)
title_sort	safety and efficacy of a feed additive consisting of bacillus subtilis strains cncm i‐4606, cncm i‐5043 and cncm i‐4607 and lactococcus lactis cncm i‐4609 for all animal species (nolivade)
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/9c3b08d7e8c244ff8a82f45044f51b71
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Safety and efficacy of a feed additive consisting of Bacillus subtilis strains CNCM I‐4606, CNCM I‐5043 and CNCM I‐4607 and Lactococcus lactis CNCM I‐4609 for all animal species (Nolivade)

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