PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target....

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Autores principales: Jingliang Zhang, Chenyu Zhang, Xiaoling Chen, Bingwei Wang, Weining Ma, Yang Yang, Ruimao Zheng, Zhuo Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9c4c3b9f0dd34dfd9978b39e043e5a31
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