PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target....

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Autores principales:	Jingliang Zhang, Chenyu Zhang, Xiaoling Chen, Bingwei Wang, Weining Ma, Yang Yang, Ruimao Zheng, Zhuo Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9c4c3b9f0dd34dfd9978b39e043e5a31
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spelling	oai:doaj.org-article:9c4c3b9f0dd34dfd9978b39e043e5a312021-12-02T11:35:57ZPKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice10.1038/s42003-021-01748-42399-3642https://doaj.org/article/9c4c3b9f0dd34dfd9978b39e043e5a312021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01748-4https://doaj.org/toc/2399-3642Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target.Jingliang ZhangChenyu ZhangXiaoling ChenBingwei WangWeining MaYang YangRuimao ZhengZhuo HuangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jingliang Zhang Chenyu Zhang Xiaoling Chen Bingwei Wang Weining Ma Yang Yang Ruimao Zheng Zhuo Huang PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
description	Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target.
format	article
author	Jingliang Zhang Chenyu Zhang Xiaoling Chen Bingwei Wang Weining Ma Yang Yang Ruimao Zheng Zhuo Huang
author_facet	Jingliang Zhang Chenyu Zhang Xiaoling Chen Bingwei Wang Weining Ma Yang Yang Ruimao Zheng Zhuo Huang
author_sort	Jingliang Zhang
title	PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
title_short	PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
title_full	PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
title_fullStr	PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
title_full_unstemmed	PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
title_sort	pka-riiβ autophosphorylation modulates pka activity and seizure phenotypes in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9c4c3b9f0dd34dfd9978b39e043e5a31
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PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

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