Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

STAT3 is a transcription factor that is activated in fibrotic diseases such as systemic sclerosis. Here the authors show that STAT3 is the converging point for multiple pro-fibrotic signalling pathways, and that its genetic ablation or inhibition ameliorate skin fibrosis in mouse models.

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Bibliographic Details
Main Authors: Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Science
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Online Access:https://doaj.org/article/9c56fd268be941fcb1e830810f66f437
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https://doaj.org/article/9c56fd268be941fcb1e830810f66f437

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