Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

STAT3 is a transcription factor that is activated in fibrotic diseases such as systemic sclerosis. Here the authors show that STAT3 is the converging point for multiple pro-fibrotic signalling pathways, and that its genetic ablation or inhibition ameliorate skin fibrosis in mouse models.

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Autores principales:	Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c56fd268be941fcb1e830810f66f437
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spelling	oai:doaj.org-article:9c56fd268be941fcb1e830810f66f4372021-12-02T14:40:22ZActivation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis10.1038/s41467-017-01236-62041-1723https://doaj.org/article/9c56fd268be941fcb1e830810f66f4372017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01236-6https://doaj.org/toc/2041-1723STAT3 is a transcription factor that is activated in fibrotic diseases such as systemic sclerosis. Here the authors show that STAT3 is the converging point for multiple pro-fibrotic signalling pathways, and that its genetic ablation or inhibition ameliorate skin fibrosis in mouse models.Debomita ChakrabortyBarbora ŠumováTatjana MallanoChih-Wei ChenAlfiya DistlerChristina BergmannIngo LudolphRaymund E. HorchKolja GelseAndreas RammingOliver DistlerGeorg SchettLadislav ŠenoltJörg H. W. DistlerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Debomita Chakraborty Barbora Šumová Tatjana Mallano Chih-Wei Chen Alfiya Distler Christina Bergmann Ingo Ludolph Raymund E. Horch Kolja Gelse Andreas Ramming Oliver Distler Georg Schett Ladislav Šenolt Jörg H. W. Distler Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
description	STAT3 is a transcription factor that is activated in fibrotic diseases such as systemic sclerosis. Here the authors show that STAT3 is the converging point for multiple pro-fibrotic signalling pathways, and that its genetic ablation or inhibition ameliorate skin fibrosis in mouse models.
format	article
author	Debomita Chakraborty Barbora Šumová Tatjana Mallano Chih-Wei Chen Alfiya Distler Christina Bergmann Ingo Ludolph Raymund E. Horch Kolja Gelse Andreas Ramming Oliver Distler Georg Schett Ladislav Šenolt Jörg H. W. Distler
author_facet	Debomita Chakraborty Barbora Šumová Tatjana Mallano Chih-Wei Chen Alfiya Distler Christina Bergmann Ingo Ludolph Raymund E. Horch Kolja Gelse Andreas Ramming Oliver Distler Georg Schett Ladislav Šenolt Jörg H. W. Distler
author_sort	Debomita Chakraborty
title	Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
title_short	Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
title_full	Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
title_fullStr	Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
title_full_unstemmed	Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
title_sort	activation of stat3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9c56fd268be941fcb1e830810f66f437
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Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

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