SALM4 negatively regulates NMDA receptor function and fear memory consolidation
To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They de...
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| Auteurs principaux: | , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/9c6821f43b5b415bb8a595e34ac8759f |
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| Résumé: | To elucidate the role of synaptic cell adhesion-like molecule 4 (SALM4) in altering synaptic function in the context of fear memory, Lie at al performed behavioural and electrophysiological assessments of SALM4 knockout mice undergoing cued fear, spatial, and object-recognition memory tasks. They demonstrated that SALM4 suppresses heightened GluN2B-expressing NMDA receptor function specifically during fear memory consolidation. |
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