Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.
Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation of a ternary complex with the transmembrane receptors Krm1/2 and Lrp5/6, thereby blocking the induction of Wnt signalli...
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Auteurs principaux: | , , , , , , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
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Public Library of Science (PLoS)
2010
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Accès en ligne: | https://doaj.org/article/9c6c239f6c7a4a1fab9fd5114bc3cb72 |
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