Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

Wnt signalling is a key pathway controlling bone formation in mice and humans. One of the regulators of this pathway is Dkk1, which antagonizes Wnt signalling through the formation of a ternary complex with the transmembrane receptors Krm1/2 and Lrp5/6, thereby blocking the induction of Wnt signalli...

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Autores principales: Jochen Schulze, Sebastian Seitz, Hiroaki Saito, Michael Schneebauer, Robert P Marshall, Anke Baranowsky, Bjoern Busse, Arndt F Schilling, Felix W Friedrich, Joachim Albers, Alexander S Spiro, Jozef Zustin, Thomas Streichert, Kristina Ellwanger, Christof Niehrs, Michael Amling, Roland Baron, Thorsten Schinke
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/9c6c239f6c7a4a1fab9fd5114bc3cb72
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