Hepatitis C Virus Indirectly Disrupts DNA Damage-Induced p53 Responses by Activating Protein Kinase R

ABSTRACT Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of live...

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Bibliographic Details
Main Authors: Jonathan K. Mitchell, Bentley R. Midkiff, Benjamin Israelow, Matthew J. Evans, Robert E. Lanford, Christopher M. Walker, Stanley M. Lemon, David R. McGivern
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
PKR
p53
Online Access:https://doaj.org/article/9c7aab5b79d24bc7ab1c2afe955f3b68
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