Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein and show that mAb binding may interfere with trim...

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Autores principales:	Liam B. King, Brandyn R. West, Crystal L. Moyer, Pavlo Gilchuk, Andrew Flyak, Philipp A. Ilinykh, Robin Bombardi, Sean Hui, Kai Huang, Alexander Bukreyev, James E. Crowe, Erica Ollmann Saphire
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9c896c7320b3408db2980180804deb30
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spelling	oai:doaj.org-article:9c896c7320b3408db2980180804deb302021-12-02T16:57:53ZCross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk10.1038/s41467-019-09732-72041-1723https://doaj.org/article/9c896c7320b3408db2980180804deb302019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09732-7https://doaj.org/toc/2041-1723Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein and show that mAb binding may interfere with trimeric bundle assembly and/or the viral membrane.Liam B. KingBrandyn R. WestCrystal L. MoyerPavlo GilchukAndrew FlyakPhilipp A. IlinykhRobin BombardiSean HuiKai HuangAlexander BukreyevJames E. CroweErica Ollmann SaphireNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liam B. King Brandyn R. West Crystal L. Moyer Pavlo Gilchuk Andrew Flyak Philipp A. Ilinykh Robin Bombardi Sean Hui Kai Huang Alexander Bukreyev James E. Crowe Erica Ollmann Saphire Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
description	Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein and show that mAb binding may interfere with trimeric bundle assembly and/or the viral membrane.
format	article
author	Liam B. King Brandyn R. West Crystal L. Moyer Pavlo Gilchuk Andrew Flyak Philipp A. Ilinykh Robin Bombardi Sean Hui Kai Huang Alexander Bukreyev James E. Crowe Erica Ollmann Saphire
author_facet	Liam B. King Brandyn R. West Crystal L. Moyer Pavlo Gilchuk Andrew Flyak Philipp A. Ilinykh Robin Bombardi Sean Hui Kai Huang Alexander Bukreyev James E. Crowe Erica Ollmann Saphire
author_sort	Liam B. King
title	Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
title_short	Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
title_full	Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
title_fullStr	Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
title_full_unstemmed	Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
title_sort	cross-reactive neutralizing human survivor monoclonal antibody bdbv223 targets the ebolavirus stalk
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9c896c7320b3408db2980180804deb30
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Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

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