Oncofetal HMGA2 effectively curbs unconstrained (+) and (−) DNA supercoiling

Abstract HMGA2 belongs to the family of the high mobility group (HMG) proteins. It binds DNA via three AT-hook domains to the minor groove of adenine-thymine (AT) rich DNA. Recently, a new function of HMGA2 as a replication fork chaperone that protects stem and cancer cells from replication fork col...

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Détails bibliographiques
Auteurs principaux: Xiaodan Zhao, Sabrina Peter, Peter Dröge, Jie Yan
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/9c95fdace04840abae38213a8de2e2ad
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