Foot-and-Mouth Disease Virus 3C Protease Antagonizes Interferon Signaling and C142T Substitution Attenuates the FMD Virus

3C protease (3Cpro), a chymotrypsin-like cysteine protease encoded by the foot-and-mouth disease virus (FMDV), plays an essential role in processing the FMDV P1 polyprotein into individual viral capsid proteins in FMDV replication. Previously, it has been shown that 3Cpro is involved in the blockage...

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Autores principales: Pathum Ekanayaka, Sung Ho Shin, Prasanna Weeratunga, Hyuncheol Lee, Tae-Hwan Kim, Kiramage Chathuranga, Ashan Subasinghe, Jong-Hyeon Park, Jong-Soo Lee
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/9cb0fd68eb60406d85ed97bf304d6fdb
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