Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice

Myeloid Protease-Activated Receptor-2 Contributes to Influenza A Virus Pathology in Mice

BackgroundInnate immune responses to influenza A virus (IAV) infection are initiated in part by toll-like receptor 3 (TLR3). TLR3-dependent signaling induces an antiviral immune response and an NFκB-dependent inflammatory response. Protease-activated receptor 2 (PAR2) inhibits the antiviral response...

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Autores principales: Randall C. Gunther, Vanthana Bharathi, Stephen D. Miles, Lauryn R. Tumey, Clare M. Schmedes, Kohei Tatsumi, Meagan D. Bridges, David Martinez, Stephanie A. Montgomery, Melinda A. Beck, Eric Camerer, Nigel Mackman, Silvio Antoniak
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
toll-like receptor 3
influenza A virus
innate immune response
macrophage
lung epithelial cell
protease-activated receptor 2 (PAR2)
Immunologic diseases. Allergy
RC581-607
Acceso en línea:https://doaj.org/article/9ce01fde26334c13975a5e0be80b3539
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https://doaj.org/article/9ce01fde26334c13975a5e0be80b3539

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