Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

The biosynthetic pathway of fusidane-type antibiotics, such as helvolic acid, is largely undiscovered. Here, the authors investigate the biosynthesis of helvolic acid, thereby determining the sequence of the enzymatic reactions involved in the process and the intermediates formed.

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Auteurs principaux:	Jian-Ming Lv, Dan Hu, Hao Gao, Tetsuo Kushiro, Takayoshi Awakawa, Guo-Dong Chen, Chuan-Xi Wang, Ikuro Abe, Xin-Sheng Yao
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/9d043d8d1f0e4010b686b64da0e4c8b7
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spelling	oai:doaj.org-article:9d043d8d1f0e4010b686b64da0e4c8b72021-12-02T14:41:22ZBiosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis10.1038/s41467-017-01813-92041-1723https://doaj.org/article/9d043d8d1f0e4010b686b64da0e4c8b72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01813-9https://doaj.org/toc/2041-1723The biosynthetic pathway of fusidane-type antibiotics, such as helvolic acid, is largely undiscovered. Here, the authors investigate the biosynthesis of helvolic acid, thereby determining the sequence of the enzymatic reactions involved in the process and the intermediates formed.Jian-Ming LvDan HuHao GaoTetsuo KushiroTakayoshi AwakawaGuo-Dong ChenChuan-Xi WangIkuro AbeXin-Sheng YaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian-Ming Lv Dan Hu Hao Gao Tetsuo Kushiro Takayoshi Awakawa Guo-Dong Chen Chuan-Xi Wang Ikuro Abe Xin-Sheng Yao Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
description	The biosynthetic pathway of fusidane-type antibiotics, such as helvolic acid, is largely undiscovered. Here, the authors investigate the biosynthesis of helvolic acid, thereby determining the sequence of the enzymatic reactions involved in the process and the intermediates formed.
format	article
author	Jian-Ming Lv Dan Hu Hao Gao Tetsuo Kushiro Takayoshi Awakawa Guo-Dong Chen Chuan-Xi Wang Ikuro Abe Xin-Sheng Yao
author_facet	Jian-Ming Lv Dan Hu Hao Gao Tetsuo Kushiro Takayoshi Awakawa Guo-Dong Chen Chuan-Xi Wang Ikuro Abe Xin-Sheng Yao
author_sort	Jian-Ming Lv
title	Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
title_short	Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
title_full	Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
title_fullStr	Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
title_full_unstemmed	Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
title_sort	biosynthesis of helvolic acid and identification of an unusual c-4-demethylation process distinct from sterol biosynthesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9d043d8d1f0e4010b686b64da0e4c8b7
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Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

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