Structural basis for cytochrome c Y67H mutant to function as a peroxidase.

The catalytic activity of cytochrome c (cyt c) to peroxidize cardiolipin to its oxidized form is required for the release of pro-apoptotic factors from mitochondria, and for execution of the subsequent apoptotic steps. However, the structural basis for this peroxidation reaction remains unclear. In...

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Auteurs principaux: Wenxian Lan, Zhonghua Wang, Zhongzheng Yang, Tianlei Ying, Xu Zhang, Xiangshi Tan, Maili Liu, Chunyang Cao, Zhong-Xian Huang
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
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Accès en ligne:https://doaj.org/article/9d23331e85b8408fb13d1d4a9eb30d75
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