A molecular switch regulating transcriptional repression and activation of PPARγ

Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse...

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Autores principales:	Jinsai Shang, Sarah A. Mosure, Jie Zheng, Richard Brust, Jared Bass, Ashley Nichols, Laura A. Solt, Patrick R. Griffin, Douglas J. Kojetin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d32e7db99b24a56b787934b31a56130
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spelling	oai:doaj.org-article:9d32e7db99b24a56b787934b31a561302021-12-02T15:39:25ZA molecular switch regulating transcriptional repression and activation of PPARγ10.1038/s41467-020-14750-x2041-1723https://doaj.org/article/9d32e7db99b24a56b787934b31a561302020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14750-xhttps://doaj.org/toc/2041-1723Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation, where helix 12 is located within the orthosteric ligand-binding pocket instead, and discuss mechanistic implications.Jinsai ShangSarah A. MosureJie ZhengRichard BrustJared BassAshley NicholsLaura A. SoltPatrick R. GriffinDouglas J. KojetinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinsai Shang Sarah A. Mosure Jie Zheng Richard Brust Jared Bass Ashley Nichols Laura A. Solt Patrick R. Griffin Douglas J. Kojetin A molecular switch regulating transcriptional repression and activation of PPARγ
description	Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism. Here the authors present two crystal structures of peroxisome proliferator-activated receptor gamma (PPARγ) in an inverse agonist/corepressor-bound transcriptionally repressive conformation, where helix 12 is located within the orthosteric ligand-binding pocket instead, and discuss mechanistic implications.
format	article
author	Jinsai Shang Sarah A. Mosure Jie Zheng Richard Brust Jared Bass Ashley Nichols Laura A. Solt Patrick R. Griffin Douglas J. Kojetin
author_facet	Jinsai Shang Sarah A. Mosure Jie Zheng Richard Brust Jared Bass Ashley Nichols Laura A. Solt Patrick R. Griffin Douglas J. Kojetin
author_sort	Jinsai Shang
title	A molecular switch regulating transcriptional repression and activation of PPARγ
title_short	A molecular switch regulating transcriptional repression and activation of PPARγ
title_full	A molecular switch regulating transcriptional repression and activation of PPARγ
title_fullStr	A molecular switch regulating transcriptional repression and activation of PPARγ
title_full_unstemmed	A molecular switch regulating transcriptional repression and activation of PPARγ
title_sort	molecular switch regulating transcriptional repression and activation of pparγ
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9d32e7db99b24a56b787934b31a56130
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A molecular switch regulating transcriptional repression and activation of PPARγ

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