Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

Abstract Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH). EETs exert vasodilatory, anti-inflammatory, anti-apoptotic, and pro-angiogenic effects. Administration of sEH in...

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Autores principales: Ranran Tu, Jillian Armstrong, Kin Sing Stephen Lee, Bruce D. Hammock, Adam Sapirstein, Raymond C. Koehler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9d390b315d5e4a4193980594c7cc235f
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