Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens.

Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens.

Vaccinia virus (VACV) encodes an anti-apoptotic Bcl-2-like protein F1 that acts as an inhibitor of caspase-9 and of the Bak/Bax checkpoint but the role of this gene in immune responses is not known. Because dendritic cells that have phagocytosed apoptotic infected cells cross-present viral antigens...

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Autores principales: Beatriz Perdiguero, Carmen Elena Gómez, Jose Luis Nájera, Carlos Oscar S Sorzano, Julie Delaloye, Rubén González-Sanz, Victoria Jiménez, Thierry Roger, Thierry Calandra, Giuseppe Pantaleo, Mariano Esteban
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9d7662e6e76447eea6096b2ae3343b52
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