Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant

Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. However, the development of mouse-adapted virus strains has revealed key mutations in the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ravi Kant, Lauri Kareinen, Teemu Smura, Tobias L. Freitag, Sawan Kumar Jha, Kari Alitalo, Seppo Meri, Tarja Sironen, Kalle Saksela, Tomas Strandin, Anja Kipar, Olli Vapalahti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV2 COVID-19 SARS-CoV-2 variants SARS-CoV-2 beta variants infections laboratory mice Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/9db092c8cdc34f92a0a8969eeb34ef38
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9db092c8cdc34f92a0a8969eeb34ef38
record_format	dspace
spelling	oai:doaj.org-article:9db092c8cdc34f92a0a8969eeb34ef382021-11-25T19:13:54ZCommon Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant10.3390/v131122631999-4915https://doaj.org/article/9db092c8cdc34f92a0a8969eeb34ef382021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2263https://doaj.org/toc/1999-4915Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. However, the development of mouse-adapted virus strains has revealed key mutations in the SARS-CoV-2 spike protein that increase infectivity, and interestingly, many of these mutations are also present in naturally occurring SARS-CoV-2 variants of concern. This suggests that these variants might have the ability to infect common laboratory mice. Herein we show that the SARS-CoV-2 beta variant attains infectibility to BALB/c mice and causes pulmonary changes within 2–3 days post infection, consistent with results seen in other murine models of COVID-19, at a reasonable virus dose (2 × 10<sup>5</sup> PFU). The findings suggest that common laboratory mice can serve as the animal model of choice for testing the effectiveness of antiviral drugs and vaccines against SARS-CoV-2.Ravi KantLauri KareinenTeemu SmuraTobias L. FreitagSawan Kumar JhaKari AlitaloSeppo MeriTarja SironenKalle SakselaTomas StrandinAnja KiparOlli VapalahtiMDPI AGarticleSARS-CoV2COVID-19SARS-CoV-2 variantsSARS-CoV-2 beta variantsinfectionslaboratory miceMicrobiologyQR1-502ENViruses, Vol 13, Iss 2263, p 2263 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV2 COVID-19 SARS-CoV-2 variants SARS-CoV-2 beta variants infections laboratory mice Microbiology QR1-502
spellingShingle	SARS-CoV2 COVID-19 SARS-CoV-2 variants SARS-CoV-2 beta variants infections laboratory mice Microbiology QR1-502 Ravi Kant Lauri Kareinen Teemu Smura Tobias L. Freitag Sawan Kumar Jha Kari Alitalo Seppo Meri Tarja Sironen Kalle Saksela Tomas Strandin Anja Kipar Olli Vapalahti Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
description	Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. However, the development of mouse-adapted virus strains has revealed key mutations in the SARS-CoV-2 spike protein that increase infectivity, and interestingly, many of these mutations are also present in naturally occurring SARS-CoV-2 variants of concern. This suggests that these variants might have the ability to infect common laboratory mice. Herein we show that the SARS-CoV-2 beta variant attains infectibility to BALB/c mice and causes pulmonary changes within 2–3 days post infection, consistent with results seen in other murine models of COVID-19, at a reasonable virus dose (2 × 10<sup>5</sup> PFU). The findings suggest that common laboratory mice can serve as the animal model of choice for testing the effectiveness of antiviral drugs and vaccines against SARS-CoV-2.
format	article
author	Ravi Kant Lauri Kareinen Teemu Smura Tobias L. Freitag Sawan Kumar Jha Kari Alitalo Seppo Meri Tarja Sironen Kalle Saksela Tomas Strandin Anja Kipar Olli Vapalahti
author_facet	Ravi Kant Lauri Kareinen Teemu Smura Tobias L. Freitag Sawan Kumar Jha Kari Alitalo Seppo Meri Tarja Sironen Kalle Saksela Tomas Strandin Anja Kipar Olli Vapalahti
author_sort	Ravi Kant
title	Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
title_short	Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
title_full	Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
title_fullStr	Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
title_full_unstemmed	Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant
title_sort	common laboratory mice are susceptible to infection with the sars-cov-2 beta variant
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9db092c8cdc34f92a0a8969eeb34ef38
work_keys_str_mv	AT ravikant commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT laurikareinen commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT teemusmura commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT tobiaslfreitag commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT sawankumarjha commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT karialitalo commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT seppomeri commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT tarjasironen commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT kallesaksela commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT tomasstrandin commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT anjakipar commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant AT ollivapalahti commonlaboratorymicearesusceptibletoinfectionwiththesarscov2betavariant
_version_	1718410172333817856

Common Laboratory Mice Are Susceptible to Infection with the SARS-CoV-2 Beta Variant

Ejemplares similares