The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Oncogenic mutations of isocitrate dehydrogenases 1 and 2 result in the production of the oncometabolite R-2-hydroxyglutarate. Here the authors show that the oncometabolite promotes mTOR activation in a PTEN/PI3K-independent manner by regulating DEPTOR stability via inhibition of KDM4A activity.

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Autores principales:	Mélissa Carbonneau, Laurence M. Gagné, Marie-Eve Lalonde, Marie-Anne Germain, Alena Motorina, Marie-Christine Guiot, Blandine Secco, Emma E. Vincent, Anthony Tumber, Laura Hulea, Jonathan Bergeman, Udo Oppermann, Russell G. Jones, Mathieu Laplante, Ivan Topisirovic, Kevin Petrecca, Marc-Étienne Huot, Frédérick A. Mallette
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9dd294f273304449b3e2d5962e483354
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spelling	oai:doaj.org-article:9dd294f273304449b3e2d5962e4833542021-12-02T17:32:37ZThe oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway10.1038/ncomms127002041-1723https://doaj.org/article/9dd294f273304449b3e2d5962e4833542016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12700https://doaj.org/toc/2041-1723Oncogenic mutations of isocitrate dehydrogenases 1 and 2 result in the production of the oncometabolite R-2-hydroxyglutarate. Here the authors show that the oncometabolite promotes mTOR activation in a PTEN/PI3K-independent manner by regulating DEPTOR stability via inhibition of KDM4A activity.Mélissa CarbonneauLaurence M. GagnéMarie-Eve LalondeMarie-Anne GermainAlena MotorinaMarie-Christine GuiotBlandine SeccoEmma E. VincentAnthony TumberLaura HuleaJonathan BergemanUdo OppermannRussell G. JonesMathieu LaplanteIvan TopisirovicKevin PetreccaMarc-Étienne HuotFrédérick A. MalletteNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mélissa Carbonneau Laurence M. Gagné Marie-Eve Lalonde Marie-Anne Germain Alena Motorina Marie-Christine Guiot Blandine Secco Emma E. Vincent Anthony Tumber Laura Hulea Jonathan Bergeman Udo Oppermann Russell G. Jones Mathieu Laplante Ivan Topisirovic Kevin Petrecca Marc-Étienne Huot Frédérick A. Mallette The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
description	Oncogenic mutations of isocitrate dehydrogenases 1 and 2 result in the production of the oncometabolite R-2-hydroxyglutarate. Here the authors show that the oncometabolite promotes mTOR activation in a PTEN/PI3K-independent manner by regulating DEPTOR stability via inhibition of KDM4A activity.
format	article
author	Mélissa Carbonneau Laurence M. Gagné Marie-Eve Lalonde Marie-Anne Germain Alena Motorina Marie-Christine Guiot Blandine Secco Emma E. Vincent Anthony Tumber Laura Hulea Jonathan Bergeman Udo Oppermann Russell G. Jones Mathieu Laplante Ivan Topisirovic Kevin Petrecca Marc-Étienne Huot Frédérick A. Mallette
author_facet	Mélissa Carbonneau Laurence M. Gagné Marie-Eve Lalonde Marie-Anne Germain Alena Motorina Marie-Christine Guiot Blandine Secco Emma E. Vincent Anthony Tumber Laura Hulea Jonathan Bergeman Udo Oppermann Russell G. Jones Mathieu Laplante Ivan Topisirovic Kevin Petrecca Marc-Étienne Huot Frédérick A. Mallette
author_sort	Mélissa Carbonneau
title	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
title_short	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
title_full	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
title_fullStr	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
title_full_unstemmed	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
title_sort	oncometabolite 2-hydroxyglutarate activates the mtor signalling pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9dd294f273304449b3e2d5962e483354
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The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

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