Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

Mutations in BRCA1 are associated with an increased risk of breast and ovarian cancer. Here the authors show that EDC4, a component of P-bodies, is a member of the BRCA1 complex with roles in stimulating end resection at breaks.

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Autores principales:	Gonzalo Hernández, María José Ramírez, Jordi Minguillón, Paco Quiles, Gorka Ruiz de Garibay, Miriam Aza-Carmona, Massimo Bogliolo, Roser Pujol, Rosario Prados-Carvajal, Juana Fernández, Nadia García, Adrià López, Sara Gutiérrez-Enríquez, Orland Diez, Javier Benítez, Mónica Salinas, Alex Teulé, Joan Brunet, Paolo Radice, Paolo Peterlongo, Detlev Schindler, Pablo Huertas, Xose S Puente, Conxi Lázaro, Miquel Àngel Pujana, Jordi Surrallés
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9dd58df3757244329f9ae097492e7706
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spelling	oai:doaj.org-article:9dd58df3757244329f9ae097492e77062021-12-02T16:56:57ZDecapping protein EDC4 regulates DNA repair and phenocopies BRCA110.1038/s41467-018-03433-32041-1723https://doaj.org/article/9dd58df3757244329f9ae097492e77062018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03433-3https://doaj.org/toc/2041-1723Mutations in BRCA1 are associated with an increased risk of breast and ovarian cancer. Here the authors show that EDC4, a component of P-bodies, is a member of the BRCA1 complex with roles in stimulating end resection at breaks.Gonzalo HernándezMaría José RamírezJordi MinguillónPaco QuilesGorka Ruiz de GaribayMiriam Aza-CarmonaMassimo BoglioloRoser PujolRosario Prados-CarvajalJuana FernándezNadia GarcíaAdrià LópezSara Gutiérrez-EnríquezOrland DiezJavier BenítezMónica SalinasAlex TeuléJoan BrunetPaolo RadicePaolo PeterlongoDetlev SchindlerPablo HuertasXose S PuenteConxi LázaroMiquel Àngel PujanaJordi SurrallésNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gonzalo Hernández María José Ramírez Jordi Minguillón Paco Quiles Gorka Ruiz de Garibay Miriam Aza-Carmona Massimo Bogliolo Roser Pujol Rosario Prados-Carvajal Juana Fernández Nadia García Adrià López Sara Gutiérrez-Enríquez Orland Diez Javier Benítez Mónica Salinas Alex Teulé Joan Brunet Paolo Radice Paolo Peterlongo Detlev Schindler Pablo Huertas Xose S Puente Conxi Lázaro Miquel Àngel Pujana Jordi Surrallés Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
description	Mutations in BRCA1 are associated with an increased risk of breast and ovarian cancer. Here the authors show that EDC4, a component of P-bodies, is a member of the BRCA1 complex with roles in stimulating end resection at breaks.
format	article
author	Gonzalo Hernández María José Ramírez Jordi Minguillón Paco Quiles Gorka Ruiz de Garibay Miriam Aza-Carmona Massimo Bogliolo Roser Pujol Rosario Prados-Carvajal Juana Fernández Nadia García Adrià López Sara Gutiérrez-Enríquez Orland Diez Javier Benítez Mónica Salinas Alex Teulé Joan Brunet Paolo Radice Paolo Peterlongo Detlev Schindler Pablo Huertas Xose S Puente Conxi Lázaro Miquel Àngel Pujana Jordi Surrallés
author_facet	Gonzalo Hernández María José Ramírez Jordi Minguillón Paco Quiles Gorka Ruiz de Garibay Miriam Aza-Carmona Massimo Bogliolo Roser Pujol Rosario Prados-Carvajal Juana Fernández Nadia García Adrià López Sara Gutiérrez-Enríquez Orland Diez Javier Benítez Mónica Salinas Alex Teulé Joan Brunet Paolo Radice Paolo Peterlongo Detlev Schindler Pablo Huertas Xose S Puente Conxi Lázaro Miquel Àngel Pujana Jordi Surrallés
author_sort	Gonzalo Hernández
title	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_short	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_full	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_fullStr	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_full_unstemmed	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_sort	decapping protein edc4 regulates dna repair and phenocopies brca1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9dd58df3757244329f9ae097492e7706
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Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

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