Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophy...

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Auteurs principaux: Julie C. Lauterborn, Pietro Scaduto, Conor D. Cox, Anton Schulmann, Gary Lynch, Christine M. Gall, C. Dirk Keene, Agenor Limon
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/9ddd9408600e45e3b0719fb352948350
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