Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophy...

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Autores principales:	Julie C. Lauterborn, Pietro Scaduto, Conor D. Cox, Anton Schulmann, Gary Lynch, Christine M. Gall, C. Dirk Keene, Agenor Limon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ddd9408600e45e3b0719fb352948350
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spelling	oai:doaj.org-article:9ddd9408600e45e3b0719fb3529483502021-12-02T15:36:11ZIncreased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease10.1038/s41467-021-22742-82041-1723https://doaj.org/article/9ddd9408600e45e3b0719fb3529483502021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22742-8https://doaj.org/toc/2041-1723Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophysiological synaptic E/I ratio in the parietal cortex.Julie C. LauterbornPietro ScadutoConor D. CoxAnton SchulmannGary LynchChristine M. GallC. Dirk KeeneAgenor LimonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julie C. Lauterborn Pietro Scaduto Conor D. Cox Anton Schulmann Gary Lynch Christine M. Gall C. Dirk Keene Agenor Limon Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
description	Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitatory shift of postsynaptic densities and the electrophysiological synaptic E/I ratio in the parietal cortex.
format	article
author	Julie C. Lauterborn Pietro Scaduto Conor D. Cox Anton Schulmann Gary Lynch Christine M. Gall C. Dirk Keene Agenor Limon
author_facet	Julie C. Lauterborn Pietro Scaduto Conor D. Cox Anton Schulmann Gary Lynch Christine M. Gall C. Dirk Keene Agenor Limon
author_sort	Julie C. Lauterborn
title	Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
title_short	Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
title_full	Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
title_fullStr	Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
title_full_unstemmed	Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease
title_sort	increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9ddd9408600e45e3b0719fb352948350
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Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

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