Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide
Bacteriophages can bind targets with only a few copies of a display peptide while most nanoparticles with thousands achieve poor binding. Here the authors form hierarchical arrangements of phage peptides to delivery siRNA across the blood brain barrier.
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Nature Portfolio
2019
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oai:doaj.org-article:9def93cd838b4e7488bbdf9487ba930d2021-12-02T14:40:19ZCrossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide10.1038/s41467-019-12554-22041-1723https://doaj.org/article/9def93cd838b4e7488bbdf9487ba930d2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12554-2https://doaj.org/toc/2041-1723Bacteriophages can bind targets with only a few copies of a display peptide while most nanoparticles with thousands achieve poor binding. Here the authors form hierarchical arrangements of phage peptides to delivery siRNA across the blood brain barrier.Lin-Ping WuDavoud AhmadvandJunan SuArnaldur HallXiaolong TanZ. Shadi FarhangraziS. Moein MoghimiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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Science Q Lin-Ping Wu Davoud Ahmadvand Junan Su Arnaldur Hall Xiaolong Tan Z. Shadi Farhangrazi S. Moein Moghimi Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
description |
Bacteriophages can bind targets with only a few copies of a display peptide while most nanoparticles with thousands achieve poor binding. Here the authors form hierarchical arrangements of phage peptides to delivery siRNA across the blood brain barrier. |
format |
article |
author |
Lin-Ping Wu Davoud Ahmadvand Junan Su Arnaldur Hall Xiaolong Tan Z. Shadi Farhangrazi S. Moein Moghimi |
author_facet |
Lin-Ping Wu Davoud Ahmadvand Junan Su Arnaldur Hall Xiaolong Tan Z. Shadi Farhangrazi S. Moein Moghimi |
author_sort |
Lin-Ping Wu |
title |
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
title_short |
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
title_full |
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
title_fullStr |
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
title_full_unstemmed |
Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
title_sort |
crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/9def93cd838b4e7488bbdf9487ba930d |
work_keys_str_mv |
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1718390314223271936 |