PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.
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Nature Portfolio
2020
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oai:doaj.org-article:9df5fd5400ec47e98903d3b9c0b42cbb2021-12-02T17:01:22ZPRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis10.1038/s41467-020-17064-02041-1723https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17064-0https://doaj.org/toc/2041-1723The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.Slim MzoughiJia Yi FongDavid PapadopoliCheryl M. KohLaura HuleaPaolo PiginiFederico Di TullioGiuseppe AndreacchioMichal Marek HoppeHeike WollmannDiana LowMatias J. CaldezYanfen PengDenis TorreJulia N. ZhaoOro UchenunuGabriele VaranoCorina-Mihaela MotofeanuManikandan LakshmananShun Xie TeoCheng Mun WunGiovanni PeriniSoo Yong TanChee Bing OngMuthafar Al-HaddawiRavisankar RajarethinamSusan Swee-Shan HueSoon Thye LimChoon Kiat OngDachuan HuangSiok-Bian NgEmily BernsteinDan HassonKeng Boon WeePhilipp KaldisAnand JeyasekharanDavid Dominguez-solaIvan TopisirovicErnesto GuccioneNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
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Science Q Slim Mzoughi Jia Yi Fong David Papadopoli Cheryl M. Koh Laura Hulea Paolo Pigini Federico Di Tullio Giuseppe Andreacchio Michal Marek Hoppe Heike Wollmann Diana Low Matias J. Caldez Yanfen Peng Denis Torre Julia N. Zhao Oro Uchenunu Gabriele Varano Corina-Mihaela Motofeanu Manikandan Lakshmanan Shun Xie Teo Cheng Mun Wun Giovanni Perini Soo Yong Tan Chee Bing Ong Muthafar Al-Haddawi Ravisankar Rajarethinam Susan Swee-Shan Hue Soon Thye Lim Choon Kiat Ong Dachuan Huang Siok-Bian Ng Emily Bernstein Dan Hasson Keng Boon Wee Philipp Kaldis Anand Jeyasekharan David Dominguez-sola Ivan Topisirovic Ernesto Guccione PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis |
| description |
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis. |
| format |
article |
| author |
Slim Mzoughi Jia Yi Fong David Papadopoli Cheryl M. Koh Laura Hulea Paolo Pigini Federico Di Tullio Giuseppe Andreacchio Michal Marek Hoppe Heike Wollmann Diana Low Matias J. Caldez Yanfen Peng Denis Torre Julia N. Zhao Oro Uchenunu Gabriele Varano Corina-Mihaela Motofeanu Manikandan Lakshmanan Shun Xie Teo Cheng Mun Wun Giovanni Perini Soo Yong Tan Chee Bing Ong Muthafar Al-Haddawi Ravisankar Rajarethinam Susan Swee-Shan Hue Soon Thye Lim Choon Kiat Ong Dachuan Huang Siok-Bian Ng Emily Bernstein Dan Hasson Keng Boon Wee Philipp Kaldis Anand Jeyasekharan David Dominguez-sola Ivan Topisirovic Ernesto Guccione |
| author_facet |
Slim Mzoughi Jia Yi Fong David Papadopoli Cheryl M. Koh Laura Hulea Paolo Pigini Federico Di Tullio Giuseppe Andreacchio Michal Marek Hoppe Heike Wollmann Diana Low Matias J. Caldez Yanfen Peng Denis Torre Julia N. Zhao Oro Uchenunu Gabriele Varano Corina-Mihaela Motofeanu Manikandan Lakshmanan Shun Xie Teo Cheng Mun Wun Giovanni Perini Soo Yong Tan Chee Bing Ong Muthafar Al-Haddawi Ravisankar Rajarethinam Susan Swee-Shan Hue Soon Thye Lim Choon Kiat Ong Dachuan Huang Siok-Bian Ng Emily Bernstein Dan Hasson Keng Boon Wee Philipp Kaldis Anand Jeyasekharan David Dominguez-sola Ivan Topisirovic Ernesto Guccione |
| author_sort |
Slim Mzoughi |
| title |
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis |
| title_short |
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis |
| title_full |
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis |
| title_fullStr |
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis |
| title_full_unstemmed |
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis |
| title_sort |
prdm15 is a key regulator of metabolism critical to sustain b-cell lymphomagenesis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb |
| work_keys_str_mv |
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1718382164168409088 |