Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

Increasing resistance of Plasmodium falciparum strains to piperaquine (PPQ) in Southeast Asia is of concern and resistance mechanisms are incompletely understood. Here, Ross et al. show that mutations in the P. falciparum chloroquine resistance transporter are rapidly increasing in prevalence in Cam...

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Autores principales:	Leila S. Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick M. Fairhurst, Frederic Ariey, Didier Menard, David A. Fidock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e15ba8777674417b0e16955209c6ccc
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spelling	oai:doaj.org-article:9e15ba8777674417b0e16955209c6ccc2021-12-02T16:49:22ZEmerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine10.1038/s41467-018-05652-02041-1723https://doaj.org/article/9e15ba8777674417b0e16955209c6ccc2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05652-0https://doaj.org/toc/2041-1723Increasing resistance of Plasmodium falciparum strains to piperaquine (PPQ) in Southeast Asia is of concern and resistance mechanisms are incompletely understood. Here, Ross et al. show that mutations in the P. falciparum chloroquine resistance transporter are rapidly increasing in prevalence in Cambodia and confer resistance to PPQ.Leila S. RossSatish K. DhingraSachel MokTomas YeoKathryn J. WichtKrittikorn KümpornsinShannon Takala-HarrisonBenoit WitkowskiRick M. FairhurstFrederic ArieyDidier MenardDavid A. FidockNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leila S. Ross Satish K. Dhingra Sachel Mok Tomas Yeo Kathryn J. Wicht Krittikorn Kümpornsin Shannon Takala-Harrison Benoit Witkowski Rick M. Fairhurst Frederic Ariey Didier Menard David A. Fidock Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
description	Increasing resistance of Plasmodium falciparum strains to piperaquine (PPQ) in Southeast Asia is of concern and resistance mechanisms are incompletely understood. Here, Ross et al. show that mutations in the P. falciparum chloroquine resistance transporter are rapidly increasing in prevalence in Cambodia and confer resistance to PPQ.
format	article
author	Leila S. Ross Satish K. Dhingra Sachel Mok Tomas Yeo Kathryn J. Wicht Krittikorn Kümpornsin Shannon Takala-Harrison Benoit Witkowski Rick M. Fairhurst Frederic Ariey Didier Menard David A. Fidock
author_facet	Leila S. Ross Satish K. Dhingra Sachel Mok Tomas Yeo Kathryn J. Wicht Krittikorn Kümpornsin Shannon Takala-Harrison Benoit Witkowski Rick M. Fairhurst Frederic Ariey Didier Menard David A. Fidock
author_sort	Leila S. Ross
title	Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
title_short	Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
title_full	Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
title_fullStr	Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
title_full_unstemmed	Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
title_sort	emerging southeast asian pfcrt mutations confer plasmodium falciparum resistance to the first-line antimalarial piperaquine
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9e15ba8777674417b0e16955209c6ccc
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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

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