Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling

Yeast helicase Prp28 promotes the first step of spliceosome remodeling. By placing a photoactivatable unnatural amino acid in Prp28, the authors capture Prp28 in action revealing its dynamic interactions and cofactor Npl3.

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Bibliographic Details
Main Authors: Fu-Lung Yeh, Shang-Lin Chang, Golam Rizvee Ahmed, Hsin-I Liu, Luh Tung, Chung-Shu Yeh, Leah Stands Lanier, Corina Maeder, Che-Min Lin, Shu-Chun Tsai, Wan-Yi Hsiao, Wei-Hau Chang, Tien-Hsien Chang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/9e81c7d52d55433ab0c6e27d3c001065
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Internet

https://doaj.org/article/9e81c7d52d55433ab0c6e27d3c001065

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