Dissecting transition cells from single-cell transcriptome data through multiscale stochastic dynamics

How to infer transient cells and cell-fate transitions from snap-shot single cell transcriptome dataset remains a major challenge. Here the authors present a multiscale approach to construct single-cell dynamical manifold, quantify cell stability, and compute transition trajectory and probability be...

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Autores principales: Peijie Zhou, Shuxiong Wang, Tiejun Li, Qing Nie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9e98a51ef4064d648221ae7674fdbde4
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