The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.

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Detalles Bibliográficos
Autores principales: Vivek Bhaskaran, Michal O. Nowicki, Mahmoud Idriss, Miguel A. Jimenez, Gianmarco Lugli, Josie L. Hayes, Ahmad Bakur Mahmoud, Rachel E. Zane, Carmela Passaro, Keith L. Ligon, Daphne Haas-Kogan, Agnieszka Bronisz, Jakub Godlewski, Sean E. Lawler, E. Antonio Chiocca, Pierpaolo Peruzzi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
Q
Acceso en línea:https://doaj.org/article/9eb6fe5b852d43329fafc6511460a696
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https://doaj.org/article/9eb6fe5b852d43329fafc6511460a696

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