The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.

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Autores principales: Vivek Bhaskaran, Michal O. Nowicki, Mahmoud Idriss, Miguel A. Jimenez, Gianmarco Lugli, Josie L. Hayes, Ahmad Bakur Mahmoud, Rachel E. Zane, Carmela Passaro, Keith L. Ligon, Daphne Haas-Kogan, Agnieszka Bronisz, Jakub Godlewski, Sean E. Lawler, E. Antonio Chiocca, Pierpaolo Peruzzi
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/9eb6fe5b852d43329fafc6511460a696
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spelling oai:doaj.org-article:9eb6fe5b852d43329fafc6511460a6962021-12-02T14:39:16ZThe functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma10.1038/s41467-019-08390-z2041-1723https://doaj.org/article/9eb6fe5b852d43329fafc6511460a6962019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08390-zhttps://doaj.org/toc/2041-1723The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.Vivek BhaskaranMichal O. NowickiMahmoud IdrissMiguel A. JimenezGianmarco LugliJosie L. HayesAhmad Bakur MahmoudRachel E. ZaneCarmela PassaroKeith L. LigonDaphne Haas-KoganAgnieszka BroniszJakub GodlewskiSean E. LawlerE. Antonio ChioccaPierpaolo PeruzziNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Vivek Bhaskaran
Michal O. Nowicki
Mahmoud Idriss
Miguel A. Jimenez
Gianmarco Lugli
Josie L. Hayes
Ahmad Bakur Mahmoud
Rachel E. Zane
Carmela Passaro
Keith L. Ligon
Daphne Haas-Kogan
Agnieszka Bronisz
Jakub Godlewski
Sean E. Lawler
E. Antonio Chiocca
Pierpaolo Peruzzi
The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
description The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.
format article
author Vivek Bhaskaran
Michal O. Nowicki
Mahmoud Idriss
Miguel A. Jimenez
Gianmarco Lugli
Josie L. Hayes
Ahmad Bakur Mahmoud
Rachel E. Zane
Carmela Passaro
Keith L. Ligon
Daphne Haas-Kogan
Agnieszka Bronisz
Jakub Godlewski
Sean E. Lawler
E. Antonio Chiocca
Pierpaolo Peruzzi
author_facet Vivek Bhaskaran
Michal O. Nowicki
Mahmoud Idriss
Miguel A. Jimenez
Gianmarco Lugli
Josie L. Hayes
Ahmad Bakur Mahmoud
Rachel E. Zane
Carmela Passaro
Keith L. Ligon
Daphne Haas-Kogan
Agnieszka Bronisz
Jakub Godlewski
Sean E. Lawler
E. Antonio Chiocca
Pierpaolo Peruzzi
author_sort Vivek Bhaskaran
title The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
title_short The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
title_full The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
title_fullStr The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
title_full_unstemmed The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
title_sort functional synergism of microrna clustering provides therapeutically relevant epigenetic interference in glioblastoma
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/9eb6fe5b852d43329fafc6511460a696
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