Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma

The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins, ultimately revealing splicing interference as a mo...

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Autores principales:	Hector H. Huang, Ian D. Ferguson, Alexis M. Thornton, Prabhakar Bastola, Christine Lam, Yu-Hsiu T. Lin, Priya Choudhry, Margarette C. Mariano, Makeba D. Marcoulis, Chin Fen Teo, Julia Malato, Paul J. Phojanakong, Thomas G. Martin, Jeffrey L. Wolf, Sandy W. Wong, Nina Shah, Byron Hann, Angela N. Brooks, Arun P. Wiita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ede6677994c4ad081bb8e902cda0b7a
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spelling	oai:doaj.org-article:9ede6677994c4ad081bb8e902cda0b7a2021-12-02T15:37:14ZProteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma10.1038/s41467-020-15521-42041-1723https://doaj.org/article/9ede6677994c4ad081bb8e902cda0b7a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15521-4https://doaj.org/toc/2041-1723The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins, ultimately revealing splicing interference as a mode of PI action as well as demonstrating the spliceosome as a specific therapeutic vulnerability in this disease.Hector H. HuangIan D. FergusonAlexis M. ThorntonPrabhakar BastolaChristine LamYu-Hsiu T. LinPriya ChoudhryMargarette C. MarianoMakeba D. MarcoulisChin Fen TeoJulia MalatoPaul J. PhojanakongThomas G. MartinJeffrey L. WolfSandy W. WongNina ShahByron HannAngela N. BrooksArun P. WiitaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hector H. Huang Ian D. Ferguson Alexis M. Thornton Prabhakar Bastola Christine Lam Yu-Hsiu T. Lin Priya Choudhry Margarette C. Mariano Makeba D. Marcoulis Chin Fen Teo Julia Malato Paul J. Phojanakong Thomas G. Martin Jeffrey L. Wolf Sandy W. Wong Nina Shah Byron Hann Angela N. Brooks Arun P. Wiita Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
description	The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins, ultimately revealing splicing interference as a mode of PI action as well as demonstrating the spliceosome as a specific therapeutic vulnerability in this disease.
format	article
author	Hector H. Huang Ian D. Ferguson Alexis M. Thornton Prabhakar Bastola Christine Lam Yu-Hsiu T. Lin Priya Choudhry Margarette C. Mariano Makeba D. Marcoulis Chin Fen Teo Julia Malato Paul J. Phojanakong Thomas G. Martin Jeffrey L. Wolf Sandy W. Wong Nina Shah Byron Hann Angela N. Brooks Arun P. Wiita
author_facet	Hector H. Huang Ian D. Ferguson Alexis M. Thornton Prabhakar Bastola Christine Lam Yu-Hsiu T. Lin Priya Choudhry Margarette C. Mariano Makeba D. Marcoulis Chin Fen Teo Julia Malato Paul J. Phojanakong Thomas G. Martin Jeffrey L. Wolf Sandy W. Wong Nina Shah Byron Hann Angela N. Brooks Arun P. Wiita
author_sort	Hector H. Huang
title	Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
title_short	Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
title_full	Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
title_fullStr	Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
title_full_unstemmed	Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
title_sort	proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9ede6677994c4ad081bb8e902cda0b7a
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Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma

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