Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

Given the opposing effects of Akt and AMP-activated protein kinase (AMPK) on metabolic homeostasis, this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis. Akt2–Ampkα2 double knockout (DKO) mice were placed on high fat diet for 5 months. Glucose metaboli...

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Bibliographic Details
Main Authors: Shuyi Wang, Jun Tao, Huaguo Chen, Machender R. Kandadi, Mingming Sun, Haixia Xu, Gary D. Lopaschuk, Yan Lu, Junmeng Zheng, Hu Peng, Jun Ren
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Akt2
AMPK
Parkin
High fat intake
Obesity
Steatosis
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/9eeb02dc06cc42c9a49a107ebabdbf0d
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https://doaj.org/article/9eeb02dc06cc42c9a49a107ebabdbf0d

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