HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation

ABSTRACT In addition to its ability to regulate HIV-1 promoter activation, the viral transactivator Tat also functions as a determinant of pathogenesis and disease progression by directly and indirectly modulating the host anti-HIV response, largely through the capacity of Tat to interact with and m...

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Autores principales: Anna Lisa Remoli, Giulia Marsili, Edvige Perrotti, Chiara Acchioni, Marco Sgarbanti, Alessandra Borsetti, John Hiscott, Angela Battistini
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
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Acceso en línea:https://doaj.org/article/9efa615d83b048c78b202507715f46d3
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