Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors
For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.
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Nature Portfolio
2018
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oai:doaj.org-article:9f191ec1c7d248d3bde26396083e9a7b2021-12-02T17:33:17ZTuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors10.1038/s41467-017-02473-52041-1723https://doaj.org/article/9f191ec1c7d248d3bde26396083e9a7b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02473-5https://doaj.org/toc/2041-1723For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates.Ye ChenJoanne M. L. HoDavid L. ShisChinmaya GuptaJames LongDaniel S. WagnerWilliam OttKrešimir JosićMatthew R. BennettNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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Science Q Ye Chen Joanne M. L. Ho David L. Shis Chinmaya Gupta James Long Daniel S. Wagner William Ott Krešimir Josić Matthew R. Bennett Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
description |
For synthetic gene circuits to behave as designed, ligand-inducible promoters should display predictable ON/OFF characteristics. Here the authors design multi-input hybrid promoters to build transcriptional logic gates. |
format |
article |
author |
Ye Chen Joanne M. L. Ho David L. Shis Chinmaya Gupta James Long Daniel S. Wagner William Ott Krešimir Josić Matthew R. Bennett |
author_facet |
Ye Chen Joanne M. L. Ho David L. Shis Chinmaya Gupta James Long Daniel S. Wagner William Ott Krešimir Josić Matthew R. Bennett |
author_sort |
Ye Chen |
title |
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
title_short |
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
title_full |
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
title_fullStr |
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
title_full_unstemmed |
Tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
title_sort |
tuning the dynamic range of bacterial promoters regulated by ligand-inducible transcription factors |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/9f191ec1c7d248d3bde26396083e9a7b |
work_keys_str_mv |
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1718380015527133184 |