Molecular Pathology of Sodium Channel Beta-Subunit Variants

The voltage-gated Na+ channel regulates the initiation and propagation of the action potential in excitable cells. The major cardiac isoform NaV1.5, encoded by SCN5A, comprises a monomer with four homologous repeats (I-IV) that each contain a voltage sensing domain (VSD) and pore domain. In native m...

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Autores principales: Paweorn Angsutararux, Wandi Zhu, Taylor L. Voelker, Jonathan R. Silva
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/9f32dc39af854d98adabd1ec00e41505
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