Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88

It remains unclear how microbial sensing during early-life colonization results in immune homeostasis rather than acute inflammation. Here the authors show that zebrafish larvae colonization suppresses intestinal MyD88, accounting for a considerable proportion of microbiota-induced alterations in im...

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Autores principales:	Bjørn E. V. Koch, Shuxin Yang, Gerda Lamers, Jens Stougaard, Herman P. Spaink
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9f5a5a4c19844be095c1293f273062d8
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spelling	oai:doaj.org-article:9f5a5a4c19844be095c1293f273062d82021-12-02T14:39:45ZIntestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD8810.1038/s41467-018-06658-42041-1723https://doaj.org/article/9f5a5a4c19844be095c1293f273062d82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06658-4https://doaj.org/toc/2041-1723It remains unclear how microbial sensing during early-life colonization results in immune homeostasis rather than acute inflammation. Here the authors show that zebrafish larvae colonization suppresses intestinal MyD88, accounting for a considerable proportion of microbiota-induced alterations in immune setpoint.Bjørn E. V. KochShuxin YangGerda LamersJens StougaardHerman P. SpainkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bjørn E. V. Koch Shuxin Yang Gerda Lamers Jens Stougaard Herman P. Spaink Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
description	It remains unclear how microbial sensing during early-life colonization results in immune homeostasis rather than acute inflammation. Here the authors show that zebrafish larvae colonization suppresses intestinal MyD88, accounting for a considerable proportion of microbiota-induced alterations in immune setpoint.
format	article
author	Bjørn E. V. Koch Shuxin Yang Gerda Lamers Jens Stougaard Herman P. Spaink
author_facet	Bjørn E. V. Koch Shuxin Yang Gerda Lamers Jens Stougaard Herman P. Spaink
author_sort	Bjørn E. V. Koch
title	Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
title_short	Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
title_full	Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
title_fullStr	Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
title_full_unstemmed	Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88
title_sort	intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of myd88
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9f5a5a4c19844be095c1293f273062d8
work_keys_str_mv	AT bjørnevkoch intestinalmicrobiomeadjuststheinnateimmunesetpointduringcolonizationthroughnegativeregulationofmyd88 AT shuxinyang intestinalmicrobiomeadjuststheinnateimmunesetpointduringcolonizationthroughnegativeregulationofmyd88 AT gerdalamers intestinalmicrobiomeadjuststheinnateimmunesetpointduringcolonizationthroughnegativeregulationofmyd88 AT jensstougaard intestinalmicrobiomeadjuststheinnateimmunesetpointduringcolonizationthroughnegativeregulationofmyd88 AT hermanpspaink intestinalmicrobiomeadjuststheinnateimmunesetpointduringcolonizationthroughnegativeregulationofmyd88
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Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88

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