ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Teresa Lambe, Alexandra J. Spencer, Kelly M. Thomas, Karen E. Gooch, Stephen Thomas, Andrew D. White, Holly E. Humphries, Daniel Wright, Sandra Belij-Rammerstorfer, Nazia Thakur, Carina Conceicao, Robert Watson, Leonie Alden, Lauren Allen, Marilyn Aram, Kevin R. Bewley, Emily Brunt, Phillip Brown, Breeze E. Cavell, Rebecca Cobb, Susan A. Fotheringham, Ciaran Gilbride, Debbie J. Harris, Catherine M. K. Ho, Laura Hunter, Chelsea L. Kennard, Stephanie Leung, Vanessa Lucas, Didier Ngabo, Kathryn A. Ryan, Hannah Sharpe, Charlotte Sarfas, Laura Sibley, Gillian S. Slack, Marta Ulaszewska, Nadina Wand, Nathan R. Wiblin, Fergus V. Gleeson, Dalan Bailey, Sally Sharpe, Sue Charlton, Francisco J. Salguero, Miles W. Carroll, Sarah C. Gilbert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9f8c33e0c50a4a85acb2b5617681d0f4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9f8c33e0c50a4a85acb2b5617681d0f4
record_format	dspace
spelling	oai:doaj.org-article:9f8c33e0c50a4a85acb2b5617681d0f42021-12-02T16:24:51ZChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models10.1038/s42003-021-02443-02399-3642https://doaj.org/article/9f8c33e0c50a4a85acb2b5617681d0f42021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02443-0https://doaj.org/toc/2399-3642Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.Teresa LambeAlexandra J. SpencerKelly M. ThomasKaren E. GoochStephen ThomasAndrew D. WhiteHolly E. HumphriesDaniel WrightSandra Belij-RammerstorferNazia ThakurCarina ConceicaoRobert WatsonLeonie AldenLauren AllenMarilyn AramKevin R. BewleyEmily BruntPhillip BrownBreeze E. CavellRebecca CobbSusan A. FotheringhamCiaran GilbrideDebbie J. HarrisCatherine M. K. HoLaura HunterChelsea L. KennardStephanie LeungVanessa LucasDidier NgaboKathryn A. RyanHannah SharpeCharlotte SarfasLaura SibleyGillian S. SlackMarta UlaszewskaNadina WandNathan R. WiblinFergus V. GleesonDalan BaileySally SharpeSue CharltonFrancisco J. SalgueroMiles W. CarrollSarah C. GilbertNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Teresa Lambe Alexandra J. Spencer Kelly M. Thomas Karen E. Gooch Stephen Thomas Andrew D. White Holly E. Humphries Daniel Wright Sandra Belij-Rammerstorfer Nazia Thakur Carina Conceicao Robert Watson Leonie Alden Lauren Allen Marilyn Aram Kevin R. Bewley Emily Brunt Phillip Brown Breeze E. Cavell Rebecca Cobb Susan A. Fotheringham Ciaran Gilbride Debbie J. Harris Catherine M. K. Ho Laura Hunter Chelsea L. Kennard Stephanie Leung Vanessa Lucas Didier Ngabo Kathryn A. Ryan Hannah Sharpe Charlotte Sarfas Laura Sibley Gillian S. Slack Marta Ulaszewska Nadina Wand Nathan R. Wiblin Fergus V. Gleeson Dalan Bailey Sally Sharpe Sue Charlton Francisco J. Salguero Miles W. Carroll Sarah C. Gilbert ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
description	Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.
format	article
author	Teresa Lambe Alexandra J. Spencer Kelly M. Thomas Karen E. Gooch Stephen Thomas Andrew D. White Holly E. Humphries Daniel Wright Sandra Belij-Rammerstorfer Nazia Thakur Carina Conceicao Robert Watson Leonie Alden Lauren Allen Marilyn Aram Kevin R. Bewley Emily Brunt Phillip Brown Breeze E. Cavell Rebecca Cobb Susan A. Fotheringham Ciaran Gilbride Debbie J. Harris Catherine M. K. Ho Laura Hunter Chelsea L. Kennard Stephanie Leung Vanessa Lucas Didier Ngabo Kathryn A. Ryan Hannah Sharpe Charlotte Sarfas Laura Sibley Gillian S. Slack Marta Ulaszewska Nadina Wand Nathan R. Wiblin Fergus V. Gleeson Dalan Bailey Sally Sharpe Sue Charlton Francisco J. Salguero Miles W. Carroll Sarah C. Gilbert
author_facet	Teresa Lambe Alexandra J. Spencer Kelly M. Thomas Karen E. Gooch Stephen Thomas Andrew D. White Holly E. Humphries Daniel Wright Sandra Belij-Rammerstorfer Nazia Thakur Carina Conceicao Robert Watson Leonie Alden Lauren Allen Marilyn Aram Kevin R. Bewley Emily Brunt Phillip Brown Breeze E. Cavell Rebecca Cobb Susan A. Fotheringham Ciaran Gilbride Debbie J. Harris Catherine M. K. Ho Laura Hunter Chelsea L. Kennard Stephanie Leung Vanessa Lucas Didier Ngabo Kathryn A. Ryan Hannah Sharpe Charlotte Sarfas Laura Sibley Gillian S. Slack Marta Ulaszewska Nadina Wand Nathan R. Wiblin Fergus V. Gleeson Dalan Bailey Sally Sharpe Sue Charlton Francisco J. Salguero Miles W. Carroll Sarah C. Gilbert
author_sort	Teresa Lambe
title	ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
title_short	ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
title_full	ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
title_fullStr	ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
title_full_unstemmed	ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
title_sort	chadox1 ncov-19 protection against sars-cov-2 in rhesus macaque and ferret challenge models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9f8c33e0c50a4a85acb2b5617681d0f4
work_keys_str_mv	AT teresalambe chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT alexandrajspencer chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT kellymthomas chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT karenegooch chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT stephenthomas chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT andrewdwhite chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT hollyehumphries chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT danielwright chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT sandrabelijrammerstorfer chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT naziathakur chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT carinaconceicao chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT robertwatson chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT leoniealden chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT laurenallen chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT marilynaram chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT kevinrbewley chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT emilybrunt chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT phillipbrown chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT breezeecavell chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT rebeccacobb chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT susanafotheringham chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT ciarangilbride chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT debbiejharris chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT catherinemkho chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT laurahunter chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT chelsealkennard chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT stephanieleung chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT vanessalucas chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT didierngabo chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT kathrynaryan chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT hannahsharpe chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT charlottesarfas chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT laurasibley chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT gilliansslack chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT martaulaszewska chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT nadinawand chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT nathanrwiblin chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT fergusvgleeson chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT dalanbailey chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT sallysharpe chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT suecharlton chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT franciscojsalguero chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT mileswcarroll chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels AT sarahcgilbert chadox1ncov19protectionagainstsarscov2inrhesusmacaqueandferretchallengemodels
_version_	1718384126609850368

ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

Ejemplares similares