Ischemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity

Ischemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity

Abstract Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI on antigen specific alloimmunity. We demonstrate that ischemia promotes alloimmune activatio...

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Bibliographic Details
Main Authors: Mayuko Uehara, Zhabiz Solhjou, Naima Banouni, Vivek Kasinath, Ye Xiaqun, Li Dai, Osman Yilmam, Mine Yilmaz, Takaharu Ichimura, Paolo Fiorina, Paulo N. Martins, Shunsuke Ohori, Indira Guleria, Omar H. Maarouf, Stefan G. Tullius, Martina M. McGrath, Reza Abdi
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/9fc14267ab754224a3f118398408edc2
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https://doaj.org/article/9fc14267ab754224a3f118398408edc2

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