Elesclomol induces copper‐dependent ferroptosis in colorectal cancer cells via degradation of ATP7A

Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments, such as oxidative stress. The copper chelator elesclomol has been reported to have considerable anticancer efficacy, but the underlying mechanisms remain largely unknown. In this study, we found that elesclomol‐med...

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Autores principales: Wei Gao, Zhao Huang, Jiufei Duan, Edouard C. Nice, Jie Lin, Canhua Huang
Formato: article
Lenguaje:EN
Publicado: Wiley 2021
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Acceso en línea:https://doaj.org/article/a004c29e4a7447ccb26c7e8b78992a28
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