Frequent GU wobble pairings reduce translation efficiency in Plasmodium falciparum

Frequent GU wobble pairings reduce translation efficiency in Plasmodium falciparum

Abstract Plasmodium falciparum genome has 81% A+T content. This nucleotide bias leads to extreme codon usage bias and culminates in frequent insertion of asparagine homorepeats in the proteome. Using recodonized GFP sequences, we show that codons decoded via G:U wobble pairing are suboptimal codons...

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Autores principales: Sherwin Chan, Jun-Hong Ch’ng, Mats Wahlgren, Jessada Thutkawkorapin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a00b8d1b6c5a4836ba5159d5faf03e89
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