Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage
Understanding which patients will respond to FOLFIRINOX therapy is important for clinical outcome. Here, the authors show that the MIR1307 is increased pancreatic cancer cell lines and inhibition of the microRNA sensitises cells to treatment.’ stratifying patients to achieve the best clinical outcom...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a029501cd4ea4989bf6d137ae286835e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a029501cd4ea4989bf6d137ae286835e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a029501cd4ea4989bf6d137ae286835e2021-11-21T12:39:00ZModulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage10.1038/s41467-021-27099-62041-1723https://doaj.org/article/a029501cd4ea4989bf6d137ae286835e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27099-6https://doaj.org/toc/2041-1723Understanding which patients will respond to FOLFIRINOX therapy is important for clinical outcome. Here, the authors show that the MIR1307 is increased pancreatic cancer cell lines and inhibition of the microRNA sensitises cells to treatment.’ stratifying patients to achieve the best clinical outcome. Here, the authors show that the MIR1307 is increased in a subgroup of human pancreatic cancers and inhibition of the microRNA in in vitro and in vivo models of pancreatic cancer sensitises cells to treatment.Pietro CarotenutoFrancesco AmatoAndrea LampisColin RaeSomaieh HedayatMaria C. PrevidiDomenico ZitoMaya RajVincenza GuzzardoFrancesco SclafaniAndrea LaneseClaudia ParisiCaterina VicentiniIan Said-HuntingfordJens C. HahneAlbert HallsworthVladimir KirkinKate YoungRuwaida BegumAndrew WotherspoonKyriakos KouvelakisSergio Xavier AzevedoVasiliki MichalareaRosie Upstill-GoddardSheela RaoDavid WatkinsNaureen StarlingAnguraj SadanandamDavid K. ChangAndrew V. BiankinNigel B. JamiesonAldo ScarpaDavid CunninghamIan ChauPaul WorkmanMatteo FassanNicola ValeriChiara BraconiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Pietro Carotenuto Francesco Amato Andrea Lampis Colin Rae Somaieh Hedayat Maria C. Previdi Domenico Zito Maya Raj Vincenza Guzzardo Francesco Sclafani Andrea Lanese Claudia Parisi Caterina Vicentini Ian Said-Huntingford Jens C. Hahne Albert Hallsworth Vladimir Kirkin Kate Young Ruwaida Begum Andrew Wotherspoon Kyriakos Kouvelakis Sergio Xavier Azevedo Vasiliki Michalarea Rosie Upstill-Goddard Sheela Rao David Watkins Naureen Starling Anguraj Sadanandam David K. Chang Andrew V. Biankin Nigel B. Jamieson Aldo Scarpa David Cunningham Ian Chau Paul Workman Matteo Fassan Nicola Valeri Chiara Braconi Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage |
| description |
Understanding which patients will respond to FOLFIRINOX therapy is important for clinical outcome. Here, the authors show that the MIR1307 is increased pancreatic cancer cell lines and inhibition of the microRNA sensitises cells to treatment.’ stratifying patients to achieve the best clinical outcome. Here, the authors show that the MIR1307 is increased in a subgroup of human pancreatic cancers and inhibition of the microRNA in in vitro and in vivo models of pancreatic cancer sensitises cells to treatment. |
| format |
article |
| author |
Pietro Carotenuto Francesco Amato Andrea Lampis Colin Rae Somaieh Hedayat Maria C. Previdi Domenico Zito Maya Raj Vincenza Guzzardo Francesco Sclafani Andrea Lanese Claudia Parisi Caterina Vicentini Ian Said-Huntingford Jens C. Hahne Albert Hallsworth Vladimir Kirkin Kate Young Ruwaida Begum Andrew Wotherspoon Kyriakos Kouvelakis Sergio Xavier Azevedo Vasiliki Michalarea Rosie Upstill-Goddard Sheela Rao David Watkins Naureen Starling Anguraj Sadanandam David K. Chang Andrew V. Biankin Nigel B. Jamieson Aldo Scarpa David Cunningham Ian Chau Paul Workman Matteo Fassan Nicola Valeri Chiara Braconi |
| author_facet |
Pietro Carotenuto Francesco Amato Andrea Lampis Colin Rae Somaieh Hedayat Maria C. Previdi Domenico Zito Maya Raj Vincenza Guzzardo Francesco Sclafani Andrea Lanese Claudia Parisi Caterina Vicentini Ian Said-Huntingford Jens C. Hahne Albert Hallsworth Vladimir Kirkin Kate Young Ruwaida Begum Andrew Wotherspoon Kyriakos Kouvelakis Sergio Xavier Azevedo Vasiliki Michalarea Rosie Upstill-Goddard Sheela Rao David Watkins Naureen Starling Anguraj Sadanandam David K. Chang Andrew V. Biankin Nigel B. Jamieson Aldo Scarpa David Cunningham Ian Chau Paul Workman Matteo Fassan Nicola Valeri Chiara Braconi |
| author_sort |
Pietro Carotenuto |
| title |
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage |
| title_short |
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage |
| title_full |
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage |
| title_fullStr |
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage |
| title_full_unstemmed |
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage |
| title_sort |
modulation of pancreatic cancer cell sensitivity to folfirinox through microrna-mediated regulation of dna damage |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a029501cd4ea4989bf6d137ae286835e |
| work_keys_str_mv |
AT pietrocarotenuto modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT francescoamato modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT andrealampis modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT colinrae modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT somaiehhedayat modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT mariacprevidi modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT domenicozito modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT mayaraj modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT vincenzaguzzardo modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT francescosclafani modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT andrealanese modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT claudiaparisi modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT caterinavicentini modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT iansaidhuntingford modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT jenschahne modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT alberthallsworth modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT vladimirkirkin modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT kateyoung modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT ruwaidabegum modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT andrewwotherspoon modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT kyriakoskouvelakis modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT sergioxavierazevedo modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT vasilikimichalarea modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT rosieupstillgoddard modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT sheelarao modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT davidwatkins modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT naureenstarling modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT angurajsadanandam modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT davidkchang modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT andrewvbiankin modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT nigelbjamieson modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT aldoscarpa modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT davidcunningham modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT ianchau modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT paulworkman modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT matteofassan modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT nicolavaleri modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage AT chiarabraconi modulationofpancreaticcancercellsensitivitytofolfirinoxthroughmicrornamediatedregulationofdnadamage |
| _version_ |
1718418903496916992 |