Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniophary...

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Autores principales:	Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a0474958863a4634a3e1c6faf8951dc5
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spelling	oai:doaj.org-article:a0474958863a4634a3e1c6faf8951dc52021-12-02T15:38:51ZStem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma10.1038/s41467-017-01992-52041-1723https://doaj.org/article/a0474958863a4634a3e1c6faf8951dc52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01992-5https://doaj.org/toc/2041-1723Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.Jose Mario Gonzalez-MeljemScott HastonGabriela CarrenoJohn R. AppsSara PozziChristina StacheGrace KaushalAlex VirasamiLeonidas PanousopoulosSeyedeh Neda Mousavy-GharavyAna GuerreroMamunur RashidNital JaniColin R. GodingThomas S. JacquesDavid J. AdamsJesus GilCynthia L. AndoniadouJuan Pedro Martinez-BarberaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jose Mario Gonzalez-Meljem Scott Haston Gabriela Carreno John R. Apps Sara Pozzi Christina Stache Grace Kaushal Alex Virasami Leonidas Panousopoulos Seyedeh Neda Mousavy-Gharavy Ana Guerrero Mamunur Rashid Nital Jani Colin R. Goding Thomas S. Jacques David J. Adams Jesus Gil Cynthia L. Andoniadou Juan Pedro Martinez-Barbera Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
description	Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.
format	article
author	Jose Mario Gonzalez-Meljem Scott Haston Gabriela Carreno John R. Apps Sara Pozzi Christina Stache Grace Kaushal Alex Virasami Leonidas Panousopoulos Seyedeh Neda Mousavy-Gharavy Ana Guerrero Mamunur Rashid Nital Jani Colin R. Goding Thomas S. Jacques David J. Adams Jesus Gil Cynthia L. Andoniadou Juan Pedro Martinez-Barbera
author_facet	Jose Mario Gonzalez-Meljem Scott Haston Gabriela Carreno John R. Apps Sara Pozzi Christina Stache Grace Kaushal Alex Virasami Leonidas Panousopoulos Seyedeh Neda Mousavy-Gharavy Ana Guerrero Mamunur Rashid Nital Jani Colin R. Goding Thomas S. Jacques David J. Adams Jesus Gil Cynthia L. Andoniadou Juan Pedro Martinez-Barbera
author_sort	Jose Mario Gonzalez-Meljem
title	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_short	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_full	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_fullStr	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_full_unstemmed	Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
title_sort	stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a0474958863a4634a3e1c6faf8951dc5
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Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

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