Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours. DKK3 is a HSF-1 effector that activates β-catenin and YA...

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Autores principales: Nicola Ferrari, Romana Ranftl, Ievgeniia Chicherova, Neil D. Slaven, Emad Moeendarbary, Aaron J. Farrugia, Maxine Lam, Maria Semiannikova, Marie C. W. Westergaard, Julia Tchou, Luca Magnani, Fernando Calvo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/a062943edfeb415ab47a681a8de56b8d
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https://doaj.org/article/a062943edfeb415ab47a681a8de56b8d

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