Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours. DKK3 is a HSF-1 effector that activates β-catenin and YA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicola Ferrari, Romana Ranftl, Ievgeniia Chicherova, Neil D. Slaven, Emad Moeendarbary, Aaron J. Farrugia, Maxine Lam, Maria Semiannikova, Marie C. W. Westergaard, Julia Tchou, Luca Magnani, Fernando Calvo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a062943edfeb415ab47a681a8de56b8d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a062943edfeb415ab47a681a8de56b8d
record_format	dspace
spelling	oai:doaj.org-article:a062943edfeb415ab47a681a8de56b8d2021-12-02T17:31:52ZDickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts10.1038/s41467-018-07987-02041-1723https://doaj.org/article/a062943edfeb415ab47a681a8de56b8d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07987-0https://doaj.org/toc/2041-1723It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours. DKK3 is a HSF-1 effector that activates β-catenin and YAP/TAZ, and DKK3-driven YAP/TAZ activation regulates the pro-tumorigenic behaviour of CAFs.Nicola FerrariRomana RanftlIevgeniia ChicherovaNeil D. SlavenEmad MoeendarbaryAaron J. FarrugiaMaxine LamMaria SemiannikovaMarie C. W. WestergaardJulia TchouLuca MagnaniFernando CalvoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicola Ferrari Romana Ranftl Ievgeniia Chicherova Neil D. Slaven Emad Moeendarbary Aaron J. Farrugia Maxine Lam Maria Semiannikova Marie C. W. Westergaard Julia Tchou Luca Magnani Fernando Calvo Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
description	It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours. DKK3 is a HSF-1 effector that activates β-catenin and YAP/TAZ, and DKK3-driven YAP/TAZ activation regulates the pro-tumorigenic behaviour of CAFs.
format	article
author	Nicola Ferrari Romana Ranftl Ievgeniia Chicherova Neil D. Slaven Emad Moeendarbary Aaron J. Farrugia Maxine Lam Maria Semiannikova Marie C. W. Westergaard Julia Tchou Luca Magnani Fernando Calvo
author_facet	Nicola Ferrari Romana Ranftl Ievgeniia Chicherova Neil D. Slaven Emad Moeendarbary Aaron J. Farrugia Maxine Lam Maria Semiannikova Marie C. W. Westergaard Julia Tchou Luca Magnani Fernando Calvo
author_sort	Nicola Ferrari
title	Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
title_short	Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
title_full	Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
title_fullStr	Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
title_full_unstemmed	Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
title_sort	dickkopf-3 links hsf1 and yap/taz signalling to control aggressive behaviours in cancer-associated fibroblasts
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a062943edfeb415ab47a681a8de56b8d
work_keys_str_mv	AT nicolaferrari dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT romanaranftl dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT ievgeniiachicherova dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT neildslaven dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT emadmoeendarbary dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT aaronjfarrugia dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT maxinelam dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT mariasemiannikova dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT mariecwwestergaard dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT juliatchou dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT lucamagnani dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts AT fernandocalvo dickkopf3linkshsf1andyaptazsignallingtocontrolaggressivebehavioursincancerassociatedfibroblasts
_version_	1718380509064593408

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

Ejemplares similares